Understanding Hormones and Your Skin

“How to achieve beautiful, supple and young-looking skin”. You almost can’t avoid it - splashed on magazine covers, reported in newspapers and marketed on television and radio, the message to improve our skin would appear paramount to how we and others view our looks.
How does our skin age?  Skin aging is influenced by:

* Genetic differences
* Hormonal changes, e.g. estrogen and thyroxin
* Chronic sun exposure
* Wind, pollution

Blame it on hormones

Hormones are mostly to blame for skin changes as we age. Hormones are chemical messengers produced in organs such as the ovaries, adrenal glands, and thyroid glands, and all have an effect on other tissues.

Much of the reason why our skin begins to suffer is primarily due to hormones — and there is a massive industry manufacturing products to try to alleviate the results of these hormonal changes, notably as women reach menopause in their 40s and 50s.

As menopause occurs, estrogen is reduced and while it has a direct effect on thinning bones, it also creates significant changes in the skin. Women find:

* their skin becomes drier with increased wrinkles
* skin becomes more fragile, loses some of its elasticity, and is looser because the production of collagen is reduced
* older skin appears paler as the lack of estrogen reduces the number of blood vessels in the skin
* menopause also causes a reduction in the level of testosterone but not as significant a drop as in estrogen

Hormones and dry skin

Another hormone we have is thyroxin, produced by the thyroid gland, which influences skin appearance. Too much thyroxin shows a warm, smooth, sweaty, flushed skin. Under-activity of thyroxin produces a dry, coarse thickening of skin with reduced ability to sweat.

Hormones affect acne

The oil glands of the skin are in part controlled by the level and activity of the hormone testosterone in the skin. Testosterone is required to produce acne. This outcome can be seen in conditions such as polycystic ovary syndrome, which produce some elevation in testosterone, which in turn causes increased facial hair, irregular periods and acne. It has also been found that some birth control pills can block testosterone skin reactors to improve some of the consequences of increasing hormone levels. (See Acne Guide for more acne information)
Thinning hair

Hair will thin after menopause. In some women, genetic factors produce significant thinning. Abnormalities in the level of a thyroid hormone, in addition to the amount of iron stored in the body, can influence the volume of hair.

Estrogen encourages hair to stay in its growing phase (Anagen hair). This is seen in the significant thickening of hair towards the end of pregnancy. After menopause, however, the lower estrogen amount allows the scalp hair to grow towards the falling out stage (Telogen hair).
HRT and skin

Post menopausal women will notice that unlike their scalp, facial hairs increase. This is thought to be because estrogen — which opposes the effect of testosterone — drops relatively more after menopause than testosterone.

Hormone replacement therapy (HRT) has been used over the last 20 years to combat the signs of aging. HRT can promote a fuller-looking skin because the skin then becomes thicker with less loss of subcutaneous fat. Thinning and drying of vaginal surfaces is also minimized. This can also be achieved by using topical estrogen. The use of estrogen creams has been shown to maintain the elasticity and fullness of skin after menopause, although at this time it is not used extensively because of concerns about side effects and the variability of absorption into the body.

See your doctor or dermatologist to determine which solutions best suits your experience with aging skin.
By Richard Thomas, MD

Can We Prevent Aging?

People are living longer. In 1970, the average life expectancy at birth was 70.8 years; in 2000, it was 76.9 years; and by 2030 is it estimated that the “oldest-old,” age 85 and older, could grow to 10 million people.Views on aging are also changing. It no longer necessarily means physical decline and illness—in the last two decades, the rate of disability among older people has declined dramatically.

The National Institute on Aging (NIA), part of the Federal Government’s National Institutes of Health (NIH), investigates ways to support healthy aging and prevent or delay the onset of diseases that disproportionately affect us as we age. These studies not only may increase what is known as “active life expectancy”—the time of advancing years free of disability—but also may promote longevity. NIA’s research includes hormone and dietary approaches, including calorie restriction.

Results from NIA-sponsored studies and others are likely to improve our understanding of the benefits and risks of hormone supplements, calorie restriction, and other interventions to promote healthy aging. This tip sheet provides an overview of what we know about hormone supplements and calorie restriction and the research needed to learn more. Until we have a better understanding, it is a good idea to be skeptical of claims that hormone or other supplements can solve your age-related problems. Instead, focus on what is known to help promote healthy aging: healthy eating and physical activity.

What Is a Hormone?

The word “hormone” comes from the Greek word, hormo, meaning to set in motion. Hormones are chemical messengers that set in motion different processes to keep our bodies working properly. For example, they are involved in our metabolism, immune function, sexual reproduction, and growth. Hormones are made by specialized groups of cells within the body’s glands. The glands—such as the pituitary, thyroid, adrenals, ovaries, and testes—release hormones into the body as needed to stimulate, regulate, and control the function of other various tissues and organs involved in biological processes.

We cannot survive without hormones. As children, hormones help us “grow up.” In teenagers, they drive puberty. As we get older, some of our hormone levels naturally decline. But what does that mean? Scientists do not know exactly. In order to know more, NIA investigates how replenishing hormones in older people affects frailty and function. Many of these studies focus on hormones that decline with age, including:

• Growth hormone
• Melatonin
• Dehydroepiandrosterone (DHEA)
• Testosterone
• Estrogen and progesterone (as part of menopausal hormone therapy)

How Hormones Work

Most hormones are typically found in very low concentrations in the bloodstream. But a hormone’s concentration will fluctuate depending on the body’s activity. Like a key that unlocks a door, a hormone molecule is released by a gland and travels through the blood until it finds a cell with the right fit, a “receptor.” The hormone latches onto a cell’s receptor and a signal is sent into the cell. These signals may instruct the cell to multiply, make proteins or enzymes, or perform other vital tasks. Some hormones can even cause a cell to release other hormones.

One hormone may fit with many types of cells but may not affect all cells in the same way. For example, one hormone may stimulate one cell to perform a task but it might also turn off a different cell. Additionally, how a cell responds to a hormone may change throughout life.

For more information on health and aging, contact:

National Institute on Aging Information Center
P.O. Box 8057
Gaithersburg, MD 20898-8057
800-222-2225 (toll-free)
800-222-4225 (TTY/toll-free)
www.nia.nih.gov